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SCIENTIFIC APPROACH

Cellular processes are fundamentally controlled at the protein level, and all proteins are produced via translation of messenger RNA (mRNA).  Cancer originates through a complex series of events, including primarily via mutations that cause changes to either cellular protein content or function.  Exacerbating an already complex situation, there are often multiple unique and simultaneous mutations that shift and evolve over time within patients, thereby changing this protein landscape and behavior. 

Translation is a highly regulated cellular process and there are several pathways responsible for the production of proteins from mRNA.  One major mechanism is called CAP dependent translation, which catalyzes the production of proteins through the eukaryotic initiation factor 4F (...